NEW METABOLIC PRODUCTS OF L-CITRULLINE AND L-HOMOARGININE

L-homoarginine and cardiovascular disease.

PURPOSE OF REVIEW An increasing number of reports indicate that low levels of the endogenous amino acid L-homoarginine are linked to cardiovascular disease. In this article, we review the current findings regarding L-homoarginine metabolism and (patho-)physiology with a focus on its clinical impact. RECENT FINDINGS Recent clinical and epidemiological studies revealed a strong association of l...

Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence

L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which converts L-arginine (L-Arg) into L-citrulline (L-Cit). Our previous study revealed that chronic administration of a combination of L-Cit and L- Ar...

L-Homoarginine from Seeds of Lathyrus cicera

Barnes, J. M. & Magee, P. N. (1954). Brit. J. indu8tr. Med. 11, 167. Brouwers, J. A. J. & Emmelot, P. (1960). Exp. CeU Re8. 19, 467. Crossfill, M. L. & Widdicombe, J. G. (1961). J. Phy8iol. 158, 1. Dontenwill, W. & Mohr, U. (1961). Klin. Wschr. 89, 493. Druckrey, H., Preussmann, R., Schmahl, D. & Mfiller, M. (1961a). Naturwis8enschaften, 48, 134. Druckrey, H., Preussmann, R., Schmahl, D. & Mill...

L-Homoarginine Suppresses Exocrine Pancreas in Rats Names of authors

[Inhibitory effect of L-homoarginine on murine osteosarcoma cell proliferation].

An organ-specific alkaline phosphatase (AIP) inhibitor, L-homoarginine at 44.5 mM concentration inhibited 3H-thymidine uptake by mouse C3H/He osteosarcoma (OS) cells, while L-arginine, L-phenylalanine and L-glycine had little effect on the uptake. This inhibitory effect by L-homoarginine persisted even after the cells were washed free of the amino acid with fresh media. L-homoarginine did not a...